NVIDIA and University of Washington co-develop RFD4-Proteina for unified protein sequence and structure generation

RFD4-Proteina is a BioNeMo open model that combines protein sequence and all-atom structure generation into a single flow-matching model, reducing workflow handoffs. It can generate proteins in complex molecular contexts including other proteins, small molecules, nucleic acids, glycans, metal ions, and modified amino acids. The model pairs an autoencoder with a flow model to generate sequences and structures together around supplied constraints such as target binders or catalytic motifs. Users can access the model for free on Hugging Face Spaces during a sponsorship period from October 21 to November 4, 2026.