New protein design tool Pinal translates natural language prompts into functional protein sequences

A Chinese research team developed Pinal, a protein design tool that translates natural language prompts into functional protein sequences. The system first uses a T2struct module to convert text into a structural blueprint, then employs SAProt-T to generate amino acid sequences. The tool successfully designed functional proteins including fluorescent proteins, enzymes, and multi-protein complexes. Trained on 80 million keyword-protein pairs, Pinal aims to lower the technical barrier to protein design, enabling users without deep structural biology expertise to generate proteins by describing desired functions in everyday language.