Scientists reverse 60 years of cellular aging in lab, track rejuvenation for over 100 days

Researchers at the University of Bonn converted blood cells from an 80-year-old donor directly into neural stem cells, observing a remarkable reversal of more than 60 years of molecular aging. Using epigenetic clocks, the team tracked the gradual rejuvenation process for over 100 days, distinguishing their method from earlier techniques that reset age rapidly through an intermediate stem-cell stage. The approach offers a new way to study the biological mechanisms of aging and related diseases such as Alzheimer's. In parallel, US regulators cleared Life Biosciences to test ER-100 in human patients, with three glaucoma patients tolerating treatment for 56 days and two showing preliminary vision improvements.