Microsoft’s MAI‑DxO AI System Outperforms Generalist Doctors on Complex Cases

Microsoft’s MAI‑DxO diagnostic system achieved an 83% accuracy rate on complex medical cases from the New England Journal of Medicine, more than twice the 36% accuracy of individual primary‑care physicians. The system orchestrates multiple AI agents that interview patients, order tests, and debate diagnoses, and it can reduce costs while improving accuracy when paired with models such as OpenAI’s GPT‑5 and GPT‑5.5.