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Leash Bio Unveils Minos Pretrained Model and 6.5M-Molecule DEL Dataset

1 reports1 sources10/14/2026 updated

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Leash Bio’s Ian Quigley and team have released the Minos pretrained model alongside a new DEL (DNA‑Encoded Library) dataset containing 6.5 million molecules. The dataset is built from high‑quality protein‑small‑molecule interaction data collected using DNA‑encoding library technology, and the authors claim it can supply tens of thousands of “lab‑level” simulations to address the industry’s data‑quality challenges. The release is positioned as a tool to train reinforcement‑learning models on DEL data, potentially accelerating scientific discovery. While the dataset’s scale and claimed simulation fidelity are highlighted, independent verification of the quality and utility of the data remains pending.

Written with AI from the reporting · updated 10/14/2026

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  1. 1Unclassified fact stationOct 15, 00:00recorded Oct 15, 06:24single source

    发布Minos预印本、博客和开放数据集

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    Evidence & revisions · 1 source records
    Subject:
    thinking-machines
    Action:
    发布预印本、博客和开放数据集
    Object:
    AI playground for agents to do verifiable scientific reasoning
    Occurred (fact side):
    Oct 15, 00:00
    Latent Space ↗Report pageOriginal / first version
    Published (valid side):
    Oct 15, 04:35
    First seen (known side):
    Oct 15, 06:24
    Fact stationSingle source · one-sided claim

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Oct 15
  1. Latent SpaceRelated fact: single source
    Leash Bio releases Minos model and open dataset for lab-in-the-loop scientific reasoning

    Report first recorded Oct 15, 06:24

    Leash Bio, specializing in DNA Encoded Libraries (DELs) for high-throughput protein-small molecule interaction data, has released the Minos pre-trained model and an open dataset containing 6.5M molecules. This development enables 'lab-in-the-loop' simulations for scientific Reinforcement Learning (RL) agents, addressing previous industry challenges related to data quality and reproducibility.

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